Since the onset of HIV two decades ago, millions of people have been infected. In the absence of effective treatment and care, these too will join the ranks of many more millions of people who have died of AIDS. With such a serious threat to mankind, who is safe? Who is immune and out of the danger zone? Who can confidently stand and point a finger? Young and old, rich or poor, male and females, black, white or coloured alike, none is immune; none is safe. Some of the greatest enemies of the fight against HIV/AIDS is Stigma & Discrimination. In this issue of ACORD’s HIV/AIDS Newsletter it is aimed to share some of the causes and effects of stigma in a number of African countries where ACORD operates. ACORD’s research work on this theme is also discussed as well as the current debates going on in the HIV/AIDS scene globally.