Climate change poses global risks. These risks adversely affect women in developing countries because of their little capacity to adapt. Previous studies show that women are more vulnerable to climate change than men for a variety of reasons, including illiteracy, low socioeconomic skills, inadequate access to assets, and social isolation, among others. Thus, if empowered, women can contribute significantly to climate change adaptation and mitigation. Limited understanding exists on climate change gender impact disparity in South Sudan. Using literature and empirical data, we find that in South Sudan: Women are at the lower rung of social hierarchy, which produces imbalances that highly expose them to climate change disasters; Women have less resilience assets, rely more on natural resources, have high rate of illiteracy, low skills and low access to professional employment, which make them more vulnerable to climate change calamities than men, and Households headed by females are more vulnerable to disasters such as famine.