Since October 2016, protests around sectoral demands have degenerated into a political crisis in Cameroon’s Anglophone regions. This crisis has led to the reemergence of the Anglophone question and highlighted the limits of the Cameroonian governance model, based on centralisation and co-optation of elites. What is the Anglophone crisis about and who are the protagonists? How is it perceived by Francophones? What is the government’s response? How has the international community reacted? What role are the Anglophone diaspora and religious actors playing? The report analyses the structural factors which caused the crisis in the Anglophone regions, the strategies and motivations of the actors, and the political and economic consequences. Recommendations are formulated which aims at breaking the deadlock and rebuilding trust, with a view to facilitating a genuine dialogue and identifying sustainable solutions.